Amidino-Containing Schiff Base Copper(II) and Iron(III) Chelates as a Thrombin Inhibitor
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چکیده
منابع مشابه
Synthesis and evaluation of guanidine-containing Schiff base copper(II), zinc(II), and iron(III) chelates as trypsin inhibitors.
3-Formyl-4-hydroxyphenylguanidine hydrochloride and its Schiff base copper(II), zinc(II), and iron(III) chelates were synthesized and their inhibitory activity against bovine beta-trypsin were determined. Syntheses of Schiff base metal chelates were carried out from 3-formyl-4-hydroxyphenylguanidine, various L-amino acids, and divalent metal acetate. Their structures were established on the bas...
متن کاملChem. Pharm. Bull. 53(1) 22—26 (2005)
critical role in the blood coagulation cascade. Thrombin converts fibrinogen into fibrin which forms part of the blood clot, and activates other blood coagulation factors such as V, VIII, XIII, and protein C. Moreover, thrombin also activates blood platelets, and acts as a mitogen for various cell types. Thus, thrombin has become a special target in the design and development of antithrombotic ...
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Two Cu(II) complexes, [Cu(L1)2](NO3)2 (1) and [Cu(L2)2] (NO3)2(2), which L1 and L2 Schiff base ligands are 2-(thiophene-2-yl) -1H-imidazo [4,5-f] [1,10] phenanthroline and 2-(furane-2-yl)-1H-imidazo[4,5-f] [1,10] phenenthroline, respectively, were syn...
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Thrombin (factor IIa) and factor Xa (FXa) are key enzymes at the junction of the intrinsic and extrinsic coagulation pathways and are the most attractive pharmacological targets for the development of novel anticoagulants. Twenty non-amidino N²-thiophencarbonyl- and N²-tosyl anthranilamides 1-20 and six amidino N²-thiophencarbonyl- and N²-tosylanthranilamides 21-26 were synthesized to evaluate ...
متن کاملExperimental and theoretical characterization of a new Schiff-base ligand
Here, new N,N′-dipyridoxyl(4,4''-diaminodiphenylether) Schiff-base ligand has been synthesized and characterized by IR, 1H NMR and mass spectrometry. Also, geometry optimization and theoretical assignment of IR spectrum of the ligand have been computed by employing density functional theory (DFT) method. Two pyridine rings and benzene rings in the bridge region are not in the same plane. The ca...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2005
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.53.22